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Rejuran, also called PN or PDRN treatment, uses polynucleotide from salmon DNA to help skin repair itself. It works deep in the skin to boost collagen, calm irritation, and improve elasticity, fine lines, and pores.
Rejuran is also known for causing more pain than most other skin injections. Many international patients want the results but worry the pain will be too much to handle. This guide looks at why Rejuran hurts and the real ways to make it more comfortable.
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Rejuran hurts more than most skin boosters because of how thick its main ingredient is. PN has a high molecular weight and a thick, gel-like texture. Pushing it through narrow skin tissue creates pressure that irritates nearby nerves. The needle also needs to reach deep into the dermis to work well. This can cause a sharp, stinging feeling at each injection point. Thin-skin areas like the forehead or under the eyes often feel more sensitive. Because of this, many patients look for ways to ease the sting, from numbing cream to sedation.
This upgraded Rejuran already contains lidocaine and hyaluronic acid mixed into the injection. Clinics report it cuts pain by roughly 50% compared with original Rejuran Healer. A 2cc session typically runs ₩240,000–450,000, versus ₩120,000–250,000 for original Rejuran (as of 2026). Many patients pick HB Plus to skip the extra cost of gas or sedation. Ask your clinic if HB Plus is offered before you book.
This is the most common first option for Rejuran. A strong topical anesthetic is applied 30 to 45 minutes before treatment. Some sources report it can lower pain scores by roughly 40–60% when timed correctly (as of 2026). It works best for device-assisted Rejuran; manual syringe injections may still feel sharp. Most clinics include this free with treatment (as of 2026).
A lidocaine-based injection can numb the area more deeply than cream alone. It is often combined with topical cream for larger or more sensitive zones. Local anesthesia may cause brief redness, mild swelling, or short-term numbness. Most clinics include this free as part of the treatment (as of 2026).
You breathe this gas through a mask and stay conscious throughout treatment. It reduces pain perception and calms anxiety without putting you fully to sleep. Side effects can include mild dizziness, nausea, or headache, which usually pass quickly. It usually costs ₩70,000–150,000 per session; multi-session packages often lower the price (as of 2026).
This puts you into a deeply relaxed, sleep-like state during the procedure. You are monitored by an anesthesiologist, and you may not remember the treatment. It carries more risk than cream or gas, including drowsiness, low blood pressure, or nausea. It is not the same as general anesthesia, which is rarely needed for Rejuran. Cost usually runs ₩100,000–300,000, depending on the drug used (as of 2026). Clinics cannot offer sedation alone; it must be paired with an actual treatment.
Not every clinic offers nitrous oxide or IV sedation as a Rejuran option. If pain relief matters to you, look for a clinic that offers several methods, not just numbing cream. This gives you room to choose based on your own pain tolerance. If you're considering IV sedation, don't just pick the cheapest option. Choose a clinic where a licensed anesthesiologist monitors you throughout the procedure. This matters more than price when sedation is involved.
This guide can tell you what pain relief options exist and how they generally work. What it can't tell you is which option fits your skin, your health history, and your pain tolerance. A fair price for your specific case, and clear communication with your provider, also depend on your situation. The Contour Journal - SSC offers a free, no-obligation review of your case if you'd like a second opinion before booking.
A. Pain relief lets patients complete treatment comfortably without cutting the session short. It also helps first-time patients return for follow-up sessions, which Rejuran usually needs.
A. Yes, when performed by a licensed doctor with proper monitoring. Each method carries mild, usually short-term side effects that your doctor should explain beforehand.
A. Numbing cream is often free; nitrous oxide runs about ₩70,000–150,000, and IV sedation about ₩100,000–300,000 (as of 2026). Ask your clinic for a full quote that includes the anesthesia option you choose.
A. Sedation recovery is usually a few hours, compared to almost none with cream alone. Plan to rest at the clinic briefly and avoid driving yourself home.
A. Many clinics in Seoul, including Myeongdong, offer English-speaking staff or interpreters. Confirm this with the clinic directly before your appointment, especially for sedation.
Rejuran can be a smooth experience when the right pain relief method matches your case. From numbing cream to nitrous oxide to IV sedation, Seoul clinics offer real options. Always discuss your health history and pain relief choice with your doctor before treatment. Send your case details to The Contour Journal - SSC for a free, no-obligation pain relief and clinic recommendation — reach us via {email or phone} or /contact.
